Photocatalysis – a tool for assembling C-C and C-X bonds.
Dorota Gryko (IChO, PAN)
26 marca o godz. 1800 Gmach Technologii Chemicznej, Aula Czochralskiego, ul. Koszykowa 75.
Photochemistry has become an important tool in contemporary organic synthesis, enabling the efficient construction of carbon–carbon and carbon–heteroatom (C–X) bonds through light-driven transformations. Photoinduced electron- and energy-transfer processes provide access to reactive intermediates under mild conditions and with high functional-group tolerance, thereby expanding the scope of modern bond-forming strategies. This lecture will discuss photochemical approaches for C–C (alkylation, carboxylation, electrophile-electrophile coupling) and C–X (amination) bond assembly, highlighting the role of photocatalysis in reaction design. Alongside commonly used photocatalytic systems, the use of porphyrinoids as catalysts will be discussed as an emerging and versatile alternative. Their strong absorption in the visible region, tunable excited-state properties, and structural modularity make porphyrinoids well suited for driving a range of synthetically valuable transformations. Representative examples will illustrate how porphyrinoid catalysts (porphyrins and vitamin B12) can complement established photocatalysts in radical-mediated couplings, functionalizations, and late-stage modifications relevant to organic synthesis. Furthermore, we have shown that visible-light-driven vitamin B12 catalysis can be efficiently conducted in aqueous environments opening access to a new research area at the intersection of photocatalysis and biocatalysis.
